Blar i forfatter "Monika, Krupová"

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    • Can the absolute configuration of cyclic peptides be determined with vibrational circular dichroism? 

      Eikås, Karolina Di Remigio; Monika, Krupová; Kristoffersen, Tone; Beerepoot, Maarten; Ruud, Kenneth (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-16)
      Cyclic peptides show a wide range of biological activities, among others as antibacterial agents. These peptides are often large and flexible with multiple chiral centers. The determination of the stereochemistry of molecules with multiple chiral centers is a challenging and important task in drug development. Chiroptical spectroscopies such as vibrational circular dichroism (VCD) can ...

    • Glucagon-like peptide 1 aggregates into low-molecular-weight oligomers off-pathway to fibrillation 

      Přáda Brichtová, Eva; Monika, Krupová; Bouř, Petr; Lindo, Viv; Gomes dos Santos, Ana; Jackson, Sophie E. (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-20)
      The physical stability of peptide-based drugs is of great interest to the pharmaceutical industry. Glucagon-like peptide 1 (GLP-1) is a 31-amino acid peptide hormone, the analogs of which are frequently used in the treatment of type 2 diabetes. We investigated the physical stability of GLP-1 and its C-terminal amide derivative, GLP-1-Am, both of which aggregate into amyloid fibrils. While off-pathway ...